Identifying biomarkers for monitoring copper metabolism disorders
Biomarkers for treatment monitoring and prognostication of disorders of hepatic copper metabolism
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11117112
This study is all about Wilson disease, a condition that causes too much copper to build up in the body, and it's looking to create a helpful database of patients and their samples to learn more about the disease and find better ways to track how well treatments are working.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11117112 on ClinicalTrials.gov |
What this research studies
This research focuses on Wilson disease, a rare genetic disorder that leads to copper accumulation in the liver and other organs. The study aims to create a patient registry and biospecimen repository to better understand the disease's natural history and identify biomarkers that can indicate treatment effectiveness. By developing a method to measure 'bioavailable' copper in blood samples, researchers hope to establish how these levels correlate with patient outcomes and treatment adherence. This could ultimately help in guiding treatment decisions and improving patient prognostication.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Wilson disease or those suspected of having copper metabolism disorders.
Not a fit: Patients with other liver diseases or those not affected by copper metabolism disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for patients with Wilson disease, potentially reducing complications and enhancing quality of life.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for other metabolic disorders, suggesting potential success for this novel approach in Wilson disease.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHILSKY, MICHAEL L — YALE UNIVERSITY
- Study coordinator: SCHILSKY, MICHAEL L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
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