Identifying biomarkers for early detection of osteoarthritis
Official title: Metabolomic Profiling to Identify Candidate Biomarker Profiles and Molecular Endotypes for Osteoarthritis
Funded at Montana State University - Bozeman · NIH-10904870 · Data updated 2026-11-12
This study is looking at how certain substances in your body can help spot osteoarthritis early, which could lead to better treatment and care for the millions of people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montana State University - Bozeman NIH-funded |
| Lab location | 1 site (Bozeman, United States) |
| Project start | August 10, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $463,869 |
| NIH project number | 5R01AR081489-02 |
| Project ID | NIH-10904870 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for osteoarthritis or those experiencing early symptoms of joint pain and dysfunction.
✕Less likely to help
Patients with advanced osteoarthritis or those who do not exhibit any symptoms related to joint pain may not benefit from this research.
What this research studies
This research investigates the use of metabolomic profiling to identify potential biomarkers for osteoarthritis (OA), a condition affecting over 50 million people in the US. By analyzing the metabolites present in synovial fluid and plasma, the study aims to uncover biological markers that could facilitate early detection of OA, which is crucial for timely intervention and management. The approach focuses on understanding the metabolic changes associated with OA, potentially leading to improved clinical care and outcomes for patients. The research employs advanced biochemical analyses to characterize these metabolic profiles and their relationship to disease progression.
Why it matters
Potential benefit: If successful, this research could lead to the development of FDA-approved biomarkers that enable early detection and intervention for osteoarthritis, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using metabolomic profiling for other conditions, suggesting that this innovative approach may yield valuable insights for osteoarthritis as well.
Where this research is happening
-
Montana State University - Bozeman
Bozeman, United States Active
Researchers
- Principal investigator: June, Ronald Kent — Montana State University - Bozeman
- Study coordinator: June, Ronald Kent
Related research
Other NIH-funded projects on the same topics.
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Nanoparticles delivering an sPLA2 blocker for knee osteoarthritis
This project uses tiny, drug-filled nanoparticles to deliver an sPLA2-blocking medicine into the knee to reduce inflammation and slow knee osteoarthritis in people with painful knee OA.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.