Identifying biomarkers for chronic pain related to endometriosis
Official title: Novel biomarkers and pathways of persistent endometriosis-associated pain across the life course
Funded at University of Michigan at Ann Arbor · NIH-11074046 · Data updated 2026-11-12
This study is looking at the biological signs that might explain why some women with endometriosis experience ongoing pelvic pain, with the goal of finding ways to identify those at risk early on and develop more tailored treatments to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | March 23, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $807,304 |
| NIH project number | 5R01HD111242-03 |
| Project ID | NIH-11074046 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of reproductive age who experience persistent pelvic pain associated with endometriosis.
✕Less likely to help
Patients who do not have endometriosis or those whose pain is not related to this condition may not benefit from this research.
What this research studies
This research investigates the underlying biological markers and pathways that contribute to persistent pelvic pain associated with endometriosis. By focusing on the neuroimmune and inflammatory responses, the study aims to identify women who are at risk of developing chronic pain early in life. The approach includes analyzing biological specimens to understand how these markers correlate with pain severity and treatment outcomes. This could lead to more personalized treatment strategies for those affected by endometriosis-related pain.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for women suffering from chronic pain due to endometriosis.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for chronic pain conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: As-Sanie, Sawsan — University of Michigan at Ann Arbor
- Study coordinator: As-Sanie, Sawsan
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
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Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.