Identifying biomarkers for autoimmune encephalopathies without known antibodies
Seronegative Autoimmune Encephalopathies: Biomarker Discovery, Validation & Deep Phenotyping
This study is looking for new ways to diagnose and treat autoimmune encephalopathies, especially for patients who don't have common markers in their blood, so that we can find better treatments and help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11013828 on NIH RePORTER |
What this research studies
This research focuses on understanding autoimmune encephalopathies, particularly those cases where patients do not have detectable IgG biomarkers. The team aims to identify and validate new disease-specific biomarkers that can help in diagnosing and treating these conditions. By using advanced techniques such as immunofluorescence assays, western blots, and mass spectrometry, the researchers hope to characterize these diseases at a molecular level. The ultimate goal is to develop targeted therapies that can improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune encephalopathies who do not have detectable IgG biomarkers.
Not a fit: Patients with autoimmune encephalopathies who have identifiable IgG biomarkers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and effective treatments for patients with autoimmune encephalopathies.
How similar studies have performed: Other research has shown promise in biomarker discovery for autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Mckeon, Andrew — Mayo Clinic Rochester
- Study coordinator: Mckeon, Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.