Identifying biological markers to predict recovery from concussions in adolescents
Poly-omic predictors of symptom duration and recovery for adolescent concussion
This study is looking at how certain markers in saliva can help us understand how long it might take for teens with mild brain injuries to feel better, so we can give them the best care possible.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-11004038 on NIH RePORTER |
What this research studies
This research investigates how specific biological markers in saliva can help predict the duration of symptoms and recovery in adolescents who have experienced mild traumatic brain injuries (mTBIs). By analyzing non-coding ribonucleic acids (ncRNAs) in saliva, the study aims to provide a more accurate assessment of brain recovery compared to traditional symptom surveys. The research will involve enrolling 750 adolescents aged 13-18 who have suffered an mTBI and measuring their ncRNA levels at various time points after the injury. The goal is to develop a biologic test that can guide individualized treatment recommendations for these young patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 13-18 who have recently experienced a mild traumatic brain injury.
Not a fit: Patients outside the age range of 13-18 or those who have not suffered a mild traumatic brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective management of concussion symptoms in adolescents.
How similar studies have performed: Previous research has shown promise in using biological markers to predict recovery from concussions, making this approach both innovative and grounded in earlier findings.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Hicks, Steven Daniel — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Hicks, Steven Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.