Identifying biological markers linked to heart failure in pulmonary arterial hypertension
Official title: Proteomic Signatures Associated with Right Ventricular Failure and Mortality in Pulmonary Arterial Hypertension
Funded at University of Washington · NIH-10898609 · Data updated 2026-11-12
This study is looking at how the heart's right side works in people with pulmonary arterial hypertension (PAH) by examining blood samples to find clues that could help predict heart health and survival, with the hope of discovering new treatments to improve their condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $90,988 |
| NIH project number | 5F32HL168780-02 |
| Project ID | NIH-10898609 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension who are experiencing or at risk of right ventricular failure.
✕Less likely to help
Patients with pulmonary arterial hypertension who do not exhibit signs of right ventricular failure may not benefit from this research.
What this research studies
This research investigates the biological mechanisms behind right ventricular failure in patients with pulmonary arterial hypertension (PAH). By analyzing plasma samples from patients, the study aims to identify specific metabolic signatures that correlate with heart function and mortality. The approach utilizes advanced bioinformatics and big data techniques to uncover patterns in biological factors that may predict patient outcomes. Understanding these mechanisms could lead to new therapies targeting right heart function in PAH patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients with pulmonary arterial hypertension, potentially reducing mortality rates.
How similar studies have gone: Previous research has shown promising results in identifying metabolic signatures related to heart failure, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Pi, Hongyang — University of Washington
- Study coordinator: Pi, Hongyang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.