Identifying biological factors affecting heart health in Black Americans
Official title: Proteomic profiling to identify mechanisms of susceptibility and resilience to cardiac dysfunction in Black Americans
Funded at Ut Southwestern Medical Center · NIH-11073496 · Data updated 2026-11-12
This study is looking at how both biological and social factors affect heart failure and atrial fibrillation in Black Americans, aiming to find out why some people are healthier than others and to discover new treatments that could help prevent heart disease in their communities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $815,229 |
| NIH project number | 1R01HL172495-01A1 |
| Project ID | NIH-11073496 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include Black Americans who are at risk for or currently experiencing heart failure or atrial fibrillation.
✕Less likely to help
Patients who do not identify as Black Americans or those without cardiovascular risk factors may not benefit from this research.
What this research studies
This research investigates how biological and social factors contribute to heart failure and atrial fibrillation in Black Americans. By analyzing proteins and genes, the study aims to uncover the pathways that lead to these cardiovascular conditions and understand why some individuals are more resilient despite facing adverse social determinants of health. The research will focus on identifying specific proteins linked to heart health, which could lead to new treatments tailored for this population. Participants may contribute to a better understanding of how to prevent heart disease in their communities.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve heart health outcomes for Black Americans.
How similar studies have gone: Previous research has shown promise in using proteomic and genomic approaches to understand cardiovascular diseases, indicating potential for success in this novel investigation.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Shah, Amil M — Ut Southwestern Medical Center
- Study coordinator: Shah, Amil M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.