Identifying bacterial cell-states to improve antibiotic treatment outcomes
A blind source separation approach for deconvolution of bulk transcriptional data leads to early detection of ATF cell-states in complex bacterial populations, in vitro and in vivo
This study is looking at how some bacteria can change and become hard to treat with antibiotics, which could help doctors find better ways to diagnose and treat infections and certain cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10911826 on NIH RePORTER |
What this research studies
This research focuses on understanding transient bacterial cell-states that contribute to antibiotic treatment failure and resistance. By utilizing advanced machine learning algorithms and innovative techniques like single cell RNA sequencing, the project aims to identify and track these elusive cell-states in complex bacterial populations. This could lead to more effective diagnostic tools and treatment strategies for both bacterial infections and certain types of cancer. The approach combines computational analysis with biological insights to enhance our understanding of how these cell-states operate.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients suffering from antibiotic-resistant infections or specific types of cancer where treatment failure is a concern.
Not a fit: Patients with non-bacterial infections or those not facing issues related to antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of antibiotic resistance and improved treatment strategies for patients with bacterial infections and cancers.
How similar studies have performed: Other research has shown promise in using advanced algorithms and sequencing techniques to improve detection and treatment strategies, indicating that this approach could be effective.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Van Opijnen, Tim — Boston Children's Hospital
- Study coordinator: Van Opijnen, Tim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.