Identifying autoimmune triggers from non-coding DNA sequences
Official title: Discovery of autoimmune antigens from non-coding sequences
Funded at Hebrew University of Jerusalem · NIH-10450060 · Data updated 2026-11-12
This study is looking for new clues in our genes that could help identify the causes of certain neuroimmune diseases, like Opsoclonus Myoclonus Syndrome, so that patients can get better diagnoses and more effective treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hebrew University of Jerusalem NIH-funded |
| Lab location | 1 site (Jerusalem, Israel) |
| Project start | July 13, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $116,041 |
| NIH project number | 5R21AI164230-02 |
| Project ID | NIH-10450060 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults suffering from neuroimmune diseases with unknown causative antigens.
✕Less likely to help
Patients with well-defined autoimmune conditions that already have established antigens may not benefit from this research.
What this research studies
This research aims to discover new autoimmune antigens that may be hidden within non-coding regions of the genome, which are often overlooked in traditional studies. By utilizing advanced techniques like Phage immunoprecipitation and sequencing, the researchers will explore small open reading frames and transposable elements to identify potential autoantigens linked to neuroimmune diseases. This could lead to better understanding and diagnosis of conditions such as Opsoclonus Myoclonus Syndrome, which currently lack defined causative antigens. Patients may benefit from more accurate diagnoses and targeted treatments based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients with neuroimmune diseases.
How similar studies have gone: While some research has successfully identified autoantigens using similar methodologies, the exploration of non-coding sequences for this purpose is relatively novel.
Where this research is happening
-
Hebrew University of Jerusalem
Jerusalem, Israel Active
Researchers
- Principal investigator: Rosenberg, Miriam Isaaca — Hebrew University of Jerusalem
- Study coordinator: Rosenberg, Miriam Isaaca
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.