Identifying antibody markers for cryptococcosis in organ transplant patients
Official title: Antibody Biomarkers of Cryptococcosis in Immunosuppressed Solid Organ Transplant Recipients
Funded at Albert Einstein College of Medicine · NIH-10985383 · Data updated 2026-11-12
This study is looking at how certain antibodies in the blood can help predict the risk of a fungal infection called cryptococcosis in people who have received organ transplants and are taking medications to suppress their immune system, so we can find better ways to keep them safe from infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | August 19, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $199,584 |
| NIH project number | 1K23AI177939-01A1 |
| Project ID | NIH-10985383 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are about to undergo organ transplantation and will be starting immunosuppressive therapy.
✕Less likely to help
Patients who are not undergoing organ transplantation or who do not require immunosuppressive therapy may not benefit from this research.
What this research studies
This research aims to identify specific antibody biomarkers that indicate the risk of cryptococcosis in patients receiving immunosuppressive therapy after organ transplantation. The study will analyze changes in plasma immunoglobulin levels and their correlation with the risk of developing cryptococcal disease. By examining kidney transplant candidates and patients diagnosed with cryptococcosis, the research will assess how different immunosuppressive drugs affect antibody levels and functionality over time. This could help in understanding how to better protect these vulnerable patients from infections.
Why it matters
Potential benefit: If successful, this research could lead to improved screening and prevention strategies for cryptococcosis in immunosuppressed organ transplant recipients.
How similar studies have gone: Previous research has shown promising results in identifying antibody responses related to infections in immunocompromised patients, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Yoon, Hyun Ah — Albert Einstein College of Medicine
- Study coordinator: Yoon, Hyun Ah
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.