Identifying antibodies to prevent and treat monkeypox infection
B-CELL EPITOPE DISCOVERY AND MECHANISMS OF ANTIBODY PROTECTION
This study is looking at a mix of six special antibodies to see if they can help protect against monkeypox, with the hope that this could lead to better treatments for people affected by the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11169642 on NIH RePORTER |
What this research studies
This research focuses on discovering and validating specific antibodies that can protect against monkeypox virus (MPXV) infections. By investigating a cocktail of six antibodies that have shown promise in small animal models, the research aims to understand how each antibody functions in preventing or treating the infection. The study addresses the urgent need for effective prophylactic and therapeutic strategies in light of the recent global spread of monkeypox. Patients may benefit from advancements in treatment options as the research progresses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk of monkeypox infection or those who may benefit from preventive therapies.
Not a fit: Patients who are not at risk for monkeypox or those with existing immunity to the virus may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective antibody-based treatments and preventive measures against monkeypox infection.
How similar studies have performed: Other research has shown success with antibody cocktails in treating viral infections, suggesting potential for this approach in monkeypox.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Crowe, James E — Vanderbilt University Medical Center
- Study coordinator: Crowe, James E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.