Identifying and understanding atypical forms of diabetes
Center for Identification and Study of Individuals with Atypical Diabetes Mellitus
This project looks for people with uncommon types of diabetes and uses genetics, blood tests, and lab-made cell models to better describe their condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11076266 on NIH RePORTER |
What this research studies
You would be invited to join a network that focuses on diabetes that does not fit usual Type 1 or Type 2 patterns. Participants and some family members provide clinical information, blood samples for whole-genome sequencing, RNA sequencing, and metabolomics, and may provide cells used to make patient-specific stem cell models. The team combines detailed medical exams with molecular data and lab-based cell studies to discover and define distinct forms of atypical diabetes. Findings are used to classify conditions, understand causes, and point to more personalized diagnosis and treatments.
Who could benefit from this research
Good fit: Ideal candidates are people whose diabetes does not fit typical Type 1 or Type 2 patterns—for example, adult-onset, brittle, ketosis-prone, suspected monogenic (MODY), or otherwise clinically unusual cases, and willing family members.
Not a fit: People with clear-cut, classic Type 1 diabetes or typical obesity-related Type 2 diabetes without atypical features are less likely to see direct benefits from this effort.
Why it matters
Potential benefit: If successful, the work could lead to more accurate diagnoses and personalized care options for people with uncommon or unclear forms of diabetes.
How similar studies have performed: Previous work has identified some monogenic and ketosis-prone diabetes types, but combining whole-genome sequencing, metabolomics, transcriptomics, and patient-specific stem cell models in a coordinated network is relatively novel.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Philipson, Louis H. — University of Chicago
- Study coordinator: Philipson, Louis H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.