Identifying and treating specific DNA repair issues in breast cancer
Defining and Targeting Homologous Recombination Deficiency in Breast Cancer
This study is looking at how certain DNA repair problems in breast cancer can help doctors find the best treatments for patients, so if you have breast cancer, your unique genetic makeup could guide your care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10902111 on NIH RePORTER |
What this research studies
This research focuses on understanding homologous recombination deficiency (HRD) in breast cancer, which affects about 25% of patients. By sequencing double-strand junctions in tumors, the researchers aim to categorize these cancers based on their DNA repair defects. The study hypothesizes that different types of DNA repair issues lead to unique genomic signatures and varying responses to treatments. The goal is to identify the most effective therapies for patients based on their specific genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients who exhibit homologous recombination deficiency, particularly those with BRCA1 or BRCA2 mutations.
Not a fit: Patients without breast cancer or those whose tumors do not exhibit homologous recombination deficiency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for breast cancer patients with specific DNA repair deficiencies.
How similar studies have performed: Previous research has shown promising results in targeting DNA repair deficiencies in cancer, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Powell, Simon N. — Sloan-Kettering Inst Can Research
- Study coordinator: Powell, Simon N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.