Identifying and treating a serious condition after stem cell transplants
Official title: Early Detection and Treatment of Hematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy (HSCT-TMA)
Funded at Brigham and Women's Hospital · NIH-11032437 · Data updated 2026-11-12
This study is looking for early signs of a serious condition called HSCT-TMA that can happen after a stem cell transplant, and it aims to find ways to help patients by testing blood samples to see if certain markers can predict this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 19, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $143,968 |
| NIH project number | 1R03DK141708-01 |
| Project ID | NIH-11032437 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults undergoing allogeneic hematopoietic stem cell transplantation.
✕Less likely to help
Patients who are not undergoing stem cell transplantation or those who have already developed severe HSCT-TMA may not benefit from this research.
What this research studies
This research focuses on hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA), a condition that can severely affect patients following stem cell transplants. The study aims to identify early markers of HSCT-TMA and explore potential treatments to mitigate its impact. Researchers will analyze blood samples from patients before and after transplantation to determine if certain biomarkers can predict the onset of HSCT-TMA. By collaborating with experts and utilizing a large sample bank, the research seeks to improve patient outcomes through early detection and intervention.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better treatment options for patients at risk of HSCT-TMA, potentially reducing complications and improving survival rates.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for other transplant-related complications, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Gupta, Shruti — Brigham and Women's Hospital
- Study coordinator: Gupta, Shruti
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.