Identifying and preventing the return of Helicobacter pylori infections in patients.
Official title: Project 3: Molecular Risk Stratification of Gastric Precancerous Lesions
Funded at Stanford University · NIH-10932178 · Data updated 2026-11-12
This study is looking for ways to prevent Helicobacter pylori infections from coming back and to help people who are at risk of developing stomach problems by using new technology to find hidden bacteria and understand their health better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $357,876 |
| NIH project number | 5P01CA265772-02 |
| Project ID | NIH-10932178 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been treated for Helicobacter pylori but are currently Hp negative.
✕Less likely to help
Patients who have active Helicobacter pylori infections or those who have not undergone treatment may not benefit from this research.
What this research studies
This research focuses on reducing the recurrence of Helicobacter pylori (Hp) infections, which can lead to serious gastric conditions. By using advanced gene sequencing technology, the study aims to detect hidden Hp colonies that survive standard treatments. Patients who are Hp negative will be monitored through RNA sequencing to identify risk factors for gastric intestinal metaplasia. The goal is to develop a reliable test that can predict and prevent the progression of gastric diseases in these patients.
Why it matters
Potential benefit: If successful, this research could significantly lower the rates of Hp recurrence and improve outcomes for patients at risk of gastric cancer.
How similar studies have gone: Previous research has shown promise in using molecular techniques for detecting persistent infections, indicating potential success for this approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Hwang, Joo Ha — Stanford University
- Study coordinator: Hwang, Joo Ha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.