Identifying and optimizing small molecules for reproductive health issues
Official title: CHEMICAL SCREENING AND OPTIMIZATION FACILITY - PROTEIN EXPRESSION AND/OR X-RAY CRYSTALLOGRAPHY
Funded at Sri International · NIH-10942884 · Data updated 2026-11-12
This study is looking for new small medicines that could help improve reproductive health issues like infertility, polycystic ovarian syndrome, and fibroids, so that patients can have better treatment options and feel healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sri International NIH-funded |
| Lab location | 1 site (Menlo Park, United States) |
| Project start | September 29, 2023 |
| Project end | September 27, 2026 |
| Funding year | 2023 |
| Award (this year) | $261,239 |
| NIH project number | 75N94023D00006-0-759402300003-1 |
| Project ID | NIH-10942884 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing infertility, polycystic ovarian syndrome, or other reproductive health issues.
✕Less likely to help
Patients with reproductive health issues not addressed by the specific conditions studied, such as certain genetic disorders unrelated to the identified conditions, may not benefit.
What this research studies
This research focuses on discovering and refining small molecules that can address various reproductive health challenges, including infertility, polycystic ovarian syndrome, and fibroids. The approach involves using x-ray crystallography to study the structure of proteins and peptides in the presence of these small molecules, which helps in understanding their interactions and potential therapeutic effects. Patients may benefit from new treatments that improve reproductive health and address related conditions. The research aims to enhance the quality of care for individuals facing these health issues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve reproductive health and fertility outcomes for patients.
How similar studies have gone: Other research has shown success in using small molecules and structural analysis to develop treatments for reproductive health issues, indicating a promising approach.
Where this research is happening
-
Sri International
Menlo Park, United States Active
Researchers
- Principal investigator: Gong, Leyi — Sri International
- Study coordinator: Gong, Leyi
Related research
Other NIH-funded projects on the same topics.
-
ABCD-USA Consortium: A large, long-term study tracking brain development in youth
A large, long-term study at multiple sites is following thousands of children and teens to understand how their brains grow and relate to health, behavior, and environment.
-
BioCyc, MetaCyc, and EcoCyc knowledge bases expansion with AI assistance
Aims to speed up and improve the BioCyc family of knowledge bases that map genomes and metabolic pathways, using AI to accelerate data curation for researchers who study microbes and metabolism.
-
Tracking HIV, alcohol use, and brain aging with MRI
Aging people living with HIV who also have alcohol use disorder are being studied to understand how brain changes relate to balance, movement, and thinking over time using MRI.
-
NCANDA-SRI: Studying how adolescent drinking affects brain development and adulthood
A long-term study at SRI International follows teens who started drinking to see how it may change brain development and risk for alcohol use disorders as they grow into adults.
-
Brain changes behind thinking and movement problems in older people with HIV and Parkinson's
This project looks at brain changes that may explain why older people living with HIV sometimes have thinking and movement problems similar to Parkinson's.
-
ABCD brain and child development project at SRI
Following children who were 9–10 years old to learn how their brains, health, and behavior change from childhood into young adulthood.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.