Identifying and measuring tiny protein fragments using new techniques
Single molecule oligopeptide fingerprinting based on templated self-assembly of oligonucleotide structures
This study is working on a new way to find and measure tiny pieces of proteins in small samples, which could help doctors better understand health conditions by spotting small changes in these proteins.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10498483 on NIH RePORTER |
What this research studies
This research focuses on developing a novel method to identify and quantify single oligopeptide molecules from very small samples. By utilizing a self-assembly process involving organic receptors and short oligonucleotides, the study aims to create specific fingerprints for these molecules. This approach is designed to complement existing technologies like mass spectrometry, allowing for routine analysis of small protein amounts and their modifications. Patients may benefit from improved diagnostic techniques that can detect subtle changes in proteins related to their health conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve protein abnormalities or require precise protein analysis.
Not a fit: Patients with conditions unrelated to protein analysis or those who do not require detailed protein profiling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and sensitive diagnostic tests for various diseases.
How similar studies have performed: Similar research approaches have shown promise in enhancing protein analysis techniques, indicating potential for success in this novel method.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Hess, Henry — Columbia Univ New York Morningside
- Study coordinator: Hess, Henry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.