Identifying and enhancing Alzheimer's disease markers in marmosets
Project 2: Identify and enhance LOAD-related signatures in outbred and genetically-engineered marmosets
['FUNDING_OTHER'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10899743
This study is looking at how Alzheimer's disease develops in marmosets to help us understand the early changes in the brain and body, which could lead to better treatments for people with late-onset Alzheimer's.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10899743 on ClinicalTrials.gov |
What this research studies
This research investigates the early molecular and cellular changes associated with late-onset Alzheimer's disease (LOAD) using marmosets as a model. By integrating genetic, molecular, imaging, and behavioral data, the study aims to understand how these factors contribute to the disease's progression. The use of genetically-engineered marmosets allows researchers to explore variations in disease outcomes, providing insights that could lead to targeted therapies. The findings from this research may help bridge the gap between human studies and preclinical testing of potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for late-onset Alzheimer's disease or those with early symptoms of the condition.
Not a fit: Patients with early-onset Alzheimer's disease or those not exhibiting any symptoms of cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for Alzheimer's disease, improving outcomes for patients.
How similar studies have performed: Other research has shown promise in using animal models to study Alzheimer's disease, indicating that this approach could yield valuable insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARTER, GREGORY W — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: CARTER, GREGORY W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease model, Alzheimer's disease risk