Identifying aggressive prostate cancer using biomarkers
Virginia-UCLA-Toronto Biomarker Characterization Center
This study is looking for ways to better understand and manage localized prostate cancer by finding markers in urine and tissue that can help tell apart slow-growing and aggressive types of cancer, especially for patients with BRCA2 gene mutations, so that doctors can make more informed treatment decisions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project ID | NIH-10911310 on NIH RePORTER |
What this research studies
This research focuses on improving the clinical management of localized prostate cancer by distinguishing between indolent and aggressive forms of the disease. It aims to identify and validate biomarkers in prostate fluids and tumor tissues that can help in the early detection of aggressive cancer types. The study will utilize proteogenomic approaches to develop urine and tissue-based biomarkers, which will enhance risk stratification and decision-making for treatment. Patients will be monitored for grade progression and the presence of high-grade lesions, particularly those with BRCA2 gene mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are men who have been newly diagnosed with localized prostate cancer and are at risk for aggressive disease.
Not a fit: Patients with advanced prostate cancer or those who do not have localized disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate early detection of aggressive prostate cancer, allowing for timely and appropriate treatment.
How similar studies have performed: Other research has shown promise in using biomarkers for cancer detection, indicating that this approach has potential for success.
Where this research is happening
Norfolk, United States
- Old Dominion University — Norfolk, United States (Active)
Researchers
- Principal investigator: Semmes, Oliver John — Old Dominion University
- Study coordinator: Semmes, Oliver John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.