Identifying aggressive colorectal cancer through blood cell analysis
Integrative single cell analyses of inflammation-derived circulating hybrid cells to identify aggressive disease
This study is looking at a special type of cell in the blood of people with colorectal cancer to see if it can help us understand how the cancer is changing and spreading, which could lead to earlier detection and better ways to keep track of the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11063265 on NIH RePORTER |
What this research studies
This research investigates a new type of cell found in the blood of colorectal cancer patients, known as circulating hybrid cells (CHCs), which may provide critical information about the disease's progression. By analyzing these cells, researchers aim to identify specific markers that indicate aggressive disease and potential metastasis. The study employs advanced imaging techniques and single-cell analysis to characterize these hybrid cells and their role in cancer development. This approach could lead to earlier detection and better monitoring of colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those in early stages or with a history of recurrence.
Not a fit: Patients with non-cancerous conditions or those who do not have colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment strategies for colorectal cancer, potentially increasing survival rates.
How similar studies have performed: Previous research has shown promise in using circulating tumor cells as biomarkers, suggesting that this novel approach with hybrid cells may also yield significant insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Wong, Melissa H. — Oregon Health & Science University
- Study coordinator: Wong, Melissa H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.