Identifying adolescents at high risk for neurocognitive disorders
Identifying adolescents at high risk of neurocognitive disorder: Development and validation of a composite risk index
This study is looking to create a helpful tool to spot young people in Uganda who might be at risk for brain and thinking problems, especially those affected by malnutrition or HIV, so that they can get the support they need early on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10685293 on NIH RePORTER |
What this research studies
This research aims to develop and validate a composite risk index that identifies adolescents at high risk for neurocognitive disorders, particularly in lower middle-income countries. By analyzing factors such as malnutrition, immune dysfunction, and HIV status, the study will utilize machine learning techniques to create a predictive model. The research will involve a cohort of 750 Ugandan children aged 6 to 18, including those who are HIV-infected, HIV-exposed uninfected, and HIV-unexposed uninfected. The goal is to improve early identification and intervention strategies for at-risk youth.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 6 to 18 years living in lower middle-income countries, particularly those with a history of malnutrition or HIV exposure.
Not a fit: Patients who are not adolescents or those living in high-income countries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification and targeted interventions for adolescents at risk of neurocognitive disorders, potentially improving their cognitive outcomes.
How similar studies have performed: Similar research approaches have shown promise in identifying at-risk populations, but this specific composite risk index is a novel application.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Ezeamama, Amara E — Michigan State University
- Study coordinator: Ezeamama, Amara E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.