Identifying a key MRI feature to improve multiple sclerosis diagnosis
Central Vein Sign: A Diagnostic Biomarker in Multiple Sclerosis
This study is looking at a special sign seen in MRI scans that could help doctors better diagnose multiple sclerosis, especially in patients with unusual symptoms, so they can start treatment sooner and help prevent long-term problems.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10894900 on NIH RePORTER |
What this research studies
This research focuses on enhancing the diagnosis of multiple sclerosis (MS) by investigating the Central Vein Sign (CVS) observed in MRI scans. The study aims to establish CVS as a reliable diagnostic biomarker that can help differentiate MS lesions from other conditions, particularly for patients presenting atypical symptoms. By improving diagnostic accuracy, the research seeks to reduce the time to diagnosis and facilitate earlier treatment, which is crucial for preventing long-term disability. The methodology involves analyzing MRI scans to identify the presence of CVS in lesions, which could lead to more effective diagnostic criteria.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing neurological symptoms that may suggest multiple sclerosis, particularly those with atypical presentations.
Not a fit: Patients who have already been definitively diagnosed with multiple sclerosis and are receiving appropriate treatment may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate diagnoses of multiple sclerosis, allowing for timely treatment and better patient outcomes.
How similar studies have performed: Previous research has shown promise in using MRI features like the Central Vein Sign to improve diagnostic accuracy in multiple sclerosis, indicating that this approach has potential for success.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Ontaneda, Daniel — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Ontaneda, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.