Identifying a biomarker to predict type 2 diabetes after gestational diabetes
Official title: Biomarker of Pancreatic B-cell Loss Predicting Progression to Type 2 Diabetes After Gestational Diabetes
Funded at Lsu Pennington Biomedical Research Ctr · NIH-11009491 · Data updated 2026-11-12
This study is looking at how a specific type of DNA related to insulin can help predict if women who had gestational diabetes are at risk of developing type 2 diabetes later on, by checking their blood samples and health over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Pennington Biomedical Research Ctr NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $600,945 |
| NIH project number | 5R01DK132011-03 |
| Project ID | NIH-11009491 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have had gestational diabetes and are within the postpartum period.
✕Less likely to help
Patients who have not experienced gestational diabetes or are not within the postpartum timeframe may not benefit from this research.
What this research studies
This research investigates how unmethylated insulin gene DNA can predict the risk of developing type 2 diabetes in women who have previously experienced gestational diabetes. By analyzing blood samples from two large cohorts of women, one in the U.S. and another in China, the study aims to track changes in this biomarker from 6-12 weeks postpartum and several years later. Participants will undergo glucose tolerance tests and other laboratory assessments to monitor their health over time.
Why it matters
Potential benefit: If successful, this research could lead to early identification of women at risk for type 2 diabetes, allowing for timely interventions.
How similar studies have gone: Previous studies have shown promise in using biomarkers to predict diabetes risk, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Lsu Pennington Biomedical Research Ctr
Baton Rouge, United States Active
Researchers
- Principal investigator: Hu, Gang — Lsu Pennington Biomedical Research Ctr
- Study coordinator: Hu, Gang
Related research
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Blood marker for beta cell loss that predicts type 2 diabetes after gestational diabetes
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Digital twins of the hypothalamus, placenta, and gut to help manage gestational diabetes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.