ICAM-1's Functions in Lung Health and Immune Responses
Uncovering and understanding the many functions of ICAM-1 in the lungs during homeostasis and innate immune responses
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11176156
This project explores how a protein called ICAM-1 works in our lungs, both when we are healthy and when our bodies are fighting off infections like pneumonia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11176156 on ClinicalTrials.gov |
What this research studies
Our lungs contain a special protein called ICAM-1, which helps lung cells and immune cells communicate. This communication is vital for keeping our lungs healthy and for fighting off infections. This project aims to discover all the different ways ICAM-1 functions, including how it helps immune cells stick to lung cells and how it sends signals inside cells. We also want to understand how its levels change during inflammation and infection, and what happens when parts of it break off and float freely. This foundational work will help us better understand the dynamic roles ICAM-1 plays in our immune system.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical applications could benefit patients with lung inflammatory conditions or infections.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: A deeper understanding of ICAM-1 could lead to new ways to treat lung inflammation and infections, potentially improving outcomes for conditions like pneumonia.
How similar studies have performed: Previous work by this laboratory and others has shown the importance of ICAM-1 in cell adhesion and signaling during inflammatory responses.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOERSCHUK, CLAIRE M — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: DOERSCHUK, CLAIRE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.