Hydrogen sulfide and exercise in HFpEF patients and models
Official title: Role of Hydrogen Sulfide in Exercise Intolerance in HFpEF
Funded at Lsu Pennington Biomedical Research Ctr · NIH-11276012 · Data updated 2026-11-12
This grant explores how low hydrogen sulfide levels may contribute to exercise intolerance in people with HFpEF and tests whether boosting H2S could improve muscle energy use and blood flow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Pennington Biomedical Research Ctr NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | July 1, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $736,602 |
| NIH project number | 1R01HL183876-01 |
| Project ID | NIH-11276012 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with HFpEF and related cardiometabolic conditions, who may have limited exercise tolerance.
✕Less likely to help
Patients without HFpEF or those not experiencing exercise intolerance related to HFpEF may not benefit.
What this research studies
HFpEF patients often struggle with exercise, largely due to muscles not using energy efficiently and reduced blood flow. The project uses animal models and human data to understand how hydrogen sulfide levels affect muscle metabolism and vascular function in HFpEF. It will test whether providing H2S or boosting its production can restore metabolic activity in skeletal muscle and improve exercise capacity. The findings could point toward new therapies that help patients be more active and endure everyday activities.
Why it matters
Potential benefit: If successful, the work could lead to new treatments that improve exercise ability and quality of life for people with HFpEF.
How similar studies have gone: Prior studies in animals and humans suggest H2S pathways influence muscle metabolism and vascular function, with encouraging signals but not yet proven in HFpEF.
Where this research is happening
-
Lsu Pennington Biomedical Research Ctr
Baton Rouge, United States Active
Researchers
- Principal investigator: Allerton, Timothy — Lsu Pennington Biomedical Research Ctr
- Study coordinator: Allerton, Timothy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.