Humanin for Heart Protection in Aging
Cardioprotective role of Humanin in aging
This research explores how a natural peptide called Humanin might protect the heart from damage, especially as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11112399 on NIH RePORTER |
What this research studies
As we age, our hearts become more vulnerable to conditions like coronary artery disease, which can lead to heart attacks and heart failure. When the heart experiences a lack of blood flow, followed by its return, it can cause significant damage to heart muscle cells. This project looks at Humanin, a small peptide made by our body's mitochondria, which has shown promise in protecting cells from stress and injury. Researchers are studying how Humanin can reduce heart damage and improve heart function after an injury, using models that mimic human heart conditions. The goal is to understand how Humanin works to keep heart cells healthy and prevent heart failure.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals concerned about age-related cardiovascular diseases, heart attacks, and heart failure.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to protect the heart from damage during events like heart attacks, potentially preventing heart failure in older adults.
How similar studies have performed: Preliminary studies in animal models have shown that Humanin can reduce heart damage and improve heart function.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Muzumdar, Radhika Hiren — University of Pittsburgh at Pittsburgh
- Study coordinator: Muzumdar, Radhika Hiren
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.