Human prostate cell models comparing cancer in African American and European American men
Developing Functional Human Cell Models to Study Initiation and Progression of Prostate Cancer between AA and EA men
This project builds human prostate cell models to learn why prostate cancer starts and progresses differently in African American and European American men.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11321154 on NIH RePORTER |
What this research studies
Researchers will grow prostate cells taken from African American and European American men using a cell-culture method called conditional reprogramming and organoid culture. They will compare normal prostate cells and primary tumor cells to look for differences in genetics, cell behavior, and early cancer changes such as abnormal karyotypes and tumor-forming ability. Some lab-grown cells will be tested in mice to see whether they form tumors, and the team will use those results to pinpoint cellular features that might explain higher incidence and mortality in African American men.
Who could benefit from this research
Good fit: Ideal participants are African American or European American men who can provide prostate tissue samples, for example during a biopsy or prostate surgery.
Not a fit: People seeking an immediate treatment for prostate cancer are unlikely to benefit directly because this work focuses on laboratory models and biological understanding.
Why it matters
Potential benefit: If successful, this work could reveal cellular reasons for racial differences in prostate cancer and point to new ways to detect or target tumors earlier in high-risk men.
How similar studies have performed: Researchers have used organoids and conditional reprogramming to grow normal and some advanced prostate cells, but reliably culturing primary prostate tumors and linking findings to racial disparities remains a newer and developing area.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Liu, Xuefeng — Ohio State University
- Study coordinator: Liu, Xuefeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.