Human pancreas and islet analysis for Type 2 diabetes
Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D)
['FUNDING_U01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11293431
This program collects donated pancreas tissue, islets, blood, and medical records to learn how Type 2 diabetes changes insulin-producing cells.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11293431 on ClinicalTrials.gov |
What this research studies
If you or a loved one take part, the team will collect pancreas tissue, isolated islets, blood, and detailed medical history and store them in a biobank. Laboratory cores will test islet function (perifusion, calcium imaging, oxygen use), perform high-resolution imaging, and run single-cell and bulk molecular profiling such as RNA sequencing and DNA methylation. Samples and linked data will be archived and shared through an open-access database so other researchers can use them. The goal is to map cellular and molecular changes in the diabetic pancreas to guide future treatments.
Who could benefit from this research
Good fit: Ideal candidates are adults with Type 2 diabetes who can donate tissue through participating hospitals or who can contribute blood samples and medical history to the biobank.
Not a fit: People looking for immediate changes to their own treatment or those without Type 2 diabetes are unlikely to receive direct clinical benefit from participation.
Why it matters
Potential benefit: If successful, this resource could point to new drug targets, biomarkers, or personalized approaches that improve care for people with Type 2 diabetes.
How similar studies have performed: This project builds on earlier HPAP work that successfully collected pancreatic tissues and generated publicly available data, while adding newer single-cell and spatial analyses.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAESTNER, KLAUS H — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: KAESTNER, KLAUS H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus