Human lymphoma tissue atlas
Center for Human Lymphoma Spatiotemporal Atlas (HuLymSTA)
Building a detailed map of lymphoma tissues to help people with follicular and T‑cell lymphomas understand how tumors change and resist treatment.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11177041 on NIH RePORTER |
What this research studies
This project will create a high-resolution map showing where different lymphoma cells, immune cells, and blood vessels sit inside tumors and how that arrangement changes over time. Researchers will use patient tumor samples and advanced imaging and genomic tools to identify which cells and mutations appear when a slow-growing lymphoma becomes aggressive. By comparing samples from follicular lymphoma, transformed diffuse large B‑cell lymphoma, and angioimmunoblastic T‑cell lymphoma, the team hopes to spot patterns that predict progression or treatment resistance. The atlas and data will be shared with other scientists to speed development of better tests and targeted therapies.
Who could benefit from this research
Good fit: People diagnosed with follicular lymphoma, angioimmunoblastic T‑cell lymphoma, or related B‑ or T‑cell lymphomas who can donate tumor tissue or clinical data would be ideal candidates.
Not a fit: People without B‑ or T‑cell lymphomas or those unable to provide tissue samples are unlikely to receive direct benefits from participating.
Why it matters
Potential benefit: Could reveal markers that predict which lymphomas will become aggressive, enabling earlier and more targeted treatment decisions.
How similar studies have performed: Spatial tumor atlases and single‑cell profiling have given new insights in other cancers, but applying these approaches specifically to lymphoma transformation is relatively new.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Fan, Rong — Yale University
- Study coordinator: Fan, Rong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.