Human Dopamine Cell Grafts for Parkinson Disease
Human Dopamine Grafts in Alpha-Synuclein Models of Parkinson Disease
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11127717
This research explores how human dopamine cells, grown from stem cells, can be used as grafts to help people with Parkinson's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11127717 on ClinicalTrials.gov |
What this research studies
Parkinson's disease causes a progressive loss of dopamine-producing brain cells, leading to movement difficulties and other symptoms. This project aims to understand how the brain's environment affects these grafted human dopamine cells, which are designed to replace the lost cells. Researchers will study how these grafts interact with the brain's existing cells and how they might restore normal brain connections. The ultimate goal is to find better ways to use these cell therapies to regenerate lost neurons and improve brain function for patients.
Who could benefit from this research
Good fit: This foundational research is for future patients with Parkinson's disease who might benefit from cell replacement therapies.
Not a fit: Patients whose condition is not related to the loss of dopamine neurons or who are not candidates for cell-based therapies may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new cell-based therapies that regenerate lost brain cells and restore brain circuitry, potentially slowing or reversing the progression of Parkinson's disease.
How similar studies have performed: The research group has already successfully derived functional dopamine neurons from human stem cells and completed a Phase 1 clinical trial using these cells, indicating prior success with similar approaches.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TABAR, VIVIANE — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: TABAR, VIVIANE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.