Human antibody profiling to guide vaccines and antibody therapies for nairoviruses, hantaviruses, and paramyxoviruses
Research Project 4: Mining human antibody responses to inform vaccine and therapeutic design
This project looks at antibodies from people who have had or never had certain viral infections to help design better vaccines and antibody treatments for viruses like hantaviruses and paramyxoviruses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11180201 on NIH RePORTER |
What this research studies
You would be asked to give small blood samples if you have recovered from, or never had, infections caused by hantaviruses, nairoviruses, or paramyxoviruses. Researchers will sort memory and naive B cells, sequence antibody genes and proteins, and use proteomics and display technologies to find promising monoclonal antibodies. Promising antibodies will be engineered and tested, while teams map where antibodies bind on viral proteins with high-resolution imaging and test potential viral escape routes in the lab. That combined information will be used to design next-generation vaccines and broadly protective antibody cocktails.
Who could benefit from this research
Good fit: Ideal candidates are people who have recovered from infections with hantaviruses, nairoviruses, or paramyxoviruses as well as healthy volunteers willing to provide blood samples.
Not a fit: People seeking immediate treatment for an active infection or those with unrelated health issues are unlikely to receive direct clinical benefit from participating.
Why it matters
Potential benefit: Could lead to new vaccines and antibody treatments that protect against hantaviruses, nairoviruses, and paramyxoviruses.
How similar studies have performed: Similar human antibody-profiling and monoclonal-antibody discovery approaches have produced effective antibody therapies and informed vaccine design for other viruses.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Gollihar, Jimmy D — Albert Einstein College of Medicine
- Study coordinator: Gollihar, Jimmy D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.