Hub for testing new glioblastoma treatments
Therapy Evaluation Core
This project tests new drug strategies to find ones that get into and act on glioblastoma brain tumors for people with this disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11189637 on NIH RePORTER |
What this research studies
From a patient's view, researchers first run careful lab and animal work to see whether candidate drugs reach brain tumors and how they should be dosed and combined. They build models linking drug levels (PK), biological effects (PD), and tumor response to predict which approaches are most promising. Promising candidates are then moved into early human Phase 0/I trials to check safety, drug distribution in the brain, and on-target effects. The core works with a pharmacology core and a broader Glioblastoma Therapeutics Network to decide which therapies should advance to later trials.
Who could benefit from this research
Good fit: Adults with glioblastoma who are eligible for early-phase (Phase 0/I) clinical trials are the ideal candidates.
Not a fit: People without brain tumors, those with other cancer types, or patients who are not eligible for early-phase trials are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this could help identify treatments that truly reach brain tumors and improve outcomes for people with glioblastoma.
How similar studies have performed: Similar preclinical-to-Phase 0/I pipelines have produced some promising leads but many candidate therapies still fail in later-stage trials.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Sarkaria, Jann N. — Mayo Clinic Rochester
- Study coordinator: Sarkaria, Jann N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.