Hub coordinating efforts to understand human cytomegalovirus (CMV)
The Administrative Core
This program coordinates teams working to understand how human cytomegalovirus (CMV) hides in the body and reactivates, aiming to help people vulnerable to CMV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11171734 on NIH RePORTER |
What this research studies
From a patient viewpoint, this program brings together virologists to study how CMV interacts with cells, focusing on the cell signaling that controls whether the virus stays dormant or becomes active. The Administrative Core organizes five linked research projects and two scientific cores, manages communications and reporting, and supports shared resources and collaborations across institutions. Work includes laboratory studies of viral binding, cellular regulation, and signaling pathways using cell models and samples to map mechanisms of latency and reactivation. The core’s role is to keep the projects coordinated so findings can move more efficiently toward clinical relevance for people at risk of CMV complications.
Who could benefit from this research
Good fit: People most likely to benefit are those at risk of CMV complications, including organ or stem-cell transplant recipients, people on immunosuppressive therapy, and infants exposed to CMV.
Not a fit: Healthy people with no CMV risk factors or those looking for immediate clinical treatments are unlikely to get direct benefit from this administrative program in the short term.
Why it matters
Potential benefit: If successful, this work could point to new ways to prevent or treat CMV reactivation in people at risk, such as transplant recipients or immunocompromised patients.
How similar studies have performed: Previous laboratory studies have identified some signaling pathways CMV uses, but turning those findings into patient treatments remains largely unproven.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Nelson, Jay a — Oregon Health & Science University
- Study coordinator: Nelson, Jay a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.