HPV in the cervix, anus, and mouth of adolescent and young adult women
Cervical, Anal & Oral HPV Persistence/Adolescent Girls
Following mostly Black and Hispanic adolescent and young adult women over time to learn how often high-risk HPV stays, returns, or appears in the cervix, anus, and mouth after early vaccination.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11322606 on NIH RePORTER |
What this research studies
If you join, researchers will use long-term clinic records and collect cervical, anal, and oral samples and blood to test for HPV types and antibody levels. They will compare people who got the older quadrivalent HPV vaccine with those who did not and look for new or “breakthrough” infections by vaccine and non-vaccine high-risk HPV types. The team will also analyze the cervicovaginal microbiome and other molecular risk factors and track other STIs through routine follow-up visits. This work focuses on an inner-city Mount Sinai cohort that is about 95% Black or Hispanic so findings aim to be directly relevant to those communities.
Who could benefit from this research
Good fit: Adolescent and young adult women—particularly those seen at Mount Sinai’s adolescent clinic and willing to provide cervical, anal, oral, and blood samples and attend follow-up—are ideal candidates.
Not a fit: People outside the adolescent/young-adult female group, males, or those unwilling to provide samples or attend follow-up visits are unlikely to benefit directly from this cohort research.
Why it matters
Potential benefit: Findings could clarify who might need HPV booster shots or microbiome-targeted approaches to lower long-term risk of high-risk HPV and related disease.
How similar studies have performed: Previous work from this cohort and others showed the quadrivalent vaccine reduced many infections but also documented some breakthrough and rising non-vaccine high-risk HPV, so long-term follow-up is a timely extension rather than entirely untested.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Diaz, Angela — Icahn School of Medicine at Mount Sinai
- Study coordinator: Diaz, Angela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.