How zinc levels in brain cells affect neurodegenerative diseases
Regulations of organellar Zn2+ homeostasis and dynamics by TRPML1 in neurons
This study is looking at how zinc in the brain affects conditions like Alzheimer's and depression, focusing on a specific gene that may help us understand how zinc is released in brain cells, with the hope of finding new ways to help people with these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Denver (Colorado Seminary) NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10620676 on NIH RePORTER |
What this research studies
This research investigates the role of zinc ions in brain function and how their dysregulation may contribute to neurodegenerative diseases like Alzheimer's and depression. By studying a specific gene, TRPML1, which is linked to a lysosomal storage disease, the researchers aim to understand how zinc is released from cellular compartments in neurons. They will use advanced sensors to measure zinc levels and explore how these changes impact neuronal health and function. The findings could provide insights into the mechanisms behind neurodegeneration and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, depression, or related neurodegenerative disorders.
Not a fit: Patients with neurodegenerative diseases not associated with zinc dysregulation or those without a diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for Alzheimer's disease and other neurodegenerative conditions by targeting zinc homeostasis in neurons.
How similar studies have performed: Previous research has shown promising results in understanding the role of zinc in neurological diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Denver, United States
- University of Denver (Colorado Seminary) — Denver, United States (Active)
Researchers
- Principal investigator: Qin, Yan — University of Denver (Colorado Seminary)
- Study coordinator: Qin, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.