How zinc affects sperm movement and fertility
Official title: Molecular Determinants of Zinc Regulation of Mammalian Sperm
Funded at University of Pittsburgh at Pittsburgh · NIH-11170545 · Data updated 2026-11-12
This study is looking at how zinc affects sperm movement and function, especially during mating and fertilization, to help improve treatments for male infertility and develop new non-hormonal birth control options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | August 16, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $441,505 |
| NIH project number | 5R01HD110439-02 |
| Project ID | NIH-11170545 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include men experiencing infertility issues related to sperm function.
✕Less likely to help
Patients who are not male or those who do not have fertility concerns may not receive benefits from this research.
What this research studies
This research investigates the role of zinc in regulating sperm function and movement, particularly during the critical phases of mating and fertilization. It aims to understand how zinc concentrations in seminal fluid and around fertilized eggs influence sperm behavior and their ability to achieve fertilization. By exploring the mechanisms of zinc regulation, the study seeks to provide insights that could lead to new fertility treatments and non-hormonal contraceptive methods. Patients may benefit from advancements in understanding male infertility and potential new contraceptive options.
Why it matters
Potential benefit: If successful, this research could lead to improved fertility treatments for men and the development of non-hormonal contraceptive methods.
How similar studies have gone: Previous research has indicated the importance of zinc in reproductive health, suggesting that this approach has potential for success.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Carlson, Anne E — University of Pittsburgh at Pittsburgh
- Study coordinator: Carlson, Anne E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.