How zinc affects immune memory to fungal infections
Official title: Metallothionein-Zinc Axis and Macrophage Memory to Fungi
Funded at University of Cincinnati · NIH-11019744 · Data updated 2026-11-12
This study is looking at how certain immune cells can remember past fungal infections to help people with weakened immune systems, like those with AIDS, fight off these infections better, focusing on the role of zinc in this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $639,496 |
| NIH project number | 5R01AI178010-02 |
| Project ID | NIH-11019744 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with compromised immune systems, particularly those living in areas where Histoplasma infections are prevalent.
✕Less likely to help
Patients with healthy immune systems or those not at risk for fungal infections may not benefit from this research.
What this research studies
This research investigates how macrophages, a type of immune cell, can 'remember' past encounters with fungal infections, specifically Histoplasma species, which are common in certain regions of the US. The study focuses on the role of zinc and metallothioneins in enhancing the ability of these immune cells to fight off infections without needing additional signals from other immune cells. By understanding the metabolic changes that occur during this 'training' process, the research aims to improve treatment outcomes for patients with weakened immune systems, such as those with AIDS.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in patients with compromised immunity, potentially reducing the severity of fungal infections.
How similar studies have gone: Previous research has shown promising results in enhancing immune responses through trained immunity, suggesting that this approach may be effective.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Deepe, George S. — University of Cincinnati
- Study coordinator: Deepe, George S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.