How Zika virus affects DNA replication and cell growth
Perturbation of Host DNA Replication and Cell Cycle Progression by Zika Virus
This study is looking at how the Zika virus affects human brain cells, especially how it stops these cells from growing and dividing, which could help scientists find better ways to treat or prevent Zika infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project ID | NIH-10647724 on NIH RePORTER |
What this research studies
This research investigates the interactions between the Zika virus and human cells, particularly focusing on how the virus disrupts DNA replication and cell cycle progression. By studying human neural stem cells, the researchers aim to understand the mechanisms by which Zika virus impedes the growth of these cells, which is crucial for developing effective antiviral treatments and vaccines. The study will explore the DNA damage response triggered by the virus and how it leads to cell cycle arrest, potentially revealing new targets for therapeutic intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been infected with the Zika virus or are at risk of infection, particularly pregnant women and their unborn children.
Not a fit: Patients who are not affected by Zika virus or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of antiviral drugs and vaccines to combat Zika virus infections.
How similar studies have performed: Other research has shown success in understanding virus-host interactions, but this specific focus on Zika virus and its effects on DNA replication is relatively novel.
Where this research is happening
Tallahassee, United States
- Florida State University — Tallahassee, United States (Active)
Researchers
- Principal investigator: Tang, Hengli — Florida State University
- Study coordinator: Tang, Hengli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.