How zebrafish regenerate heart tissue after injury.
Mechanisms controlling epicardial-dependent promotion of heart regeneration in zebrafish.
This study is looking at how zebrafish can heal their heart after damage, which could help us find new ways to help people recover their heart muscle after a heart attack.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10861012 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which zebrafish can regenerate heart muscle after severe damage, unlike humans who typically develop scar tissue. The study focuses on the role of the epicardium, a layer of cells covering the heart, which is believed to help in the regeneration process by promoting the growth of heart muscle cells. By understanding these processes in zebrafish, researchers aim to identify ways to enhance heart regeneration in humans, particularly after heart attacks. The approach includes examining cellular and molecular responses to heart injury in zebrafish and exploring how these insights can be applied to human heart repair.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would be individuals who have experienced myocardial infarction and are seeking innovative treatment options.
Not a fit: Patients with non-cardiac conditions or those who have not experienced heart damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance heart regeneration in humans after heart attacks.
How similar studies have performed: Other research has shown promising results in enhancing heart regeneration through similar approaches, indicating potential for success in this area.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Cao, Jingli — Weill Medical Coll of Cornell Univ
- Study coordinator: Cao, Jingli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.