How zebrafish glial cells help repair spinal cord injuries
Glial cell responses promote spinal cord repair in zebrafish
This study looks at how special cells in zebrafish help heal their spinal cords after an injury, with the hope that understanding this process can lead to new treatments for people with spinal cord injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11071966 on NIH RePORTER |
What this research studies
This research investigates how glial cells in zebrafish contribute to the natural regeneration of spinal cord tissue after injury. By studying the unique responses of these cells, the research aims to identify mechanisms that promote healing and functional recovery in the spinal cord. The approach involves observing the early injury responses and the formation of a glial bridge that reconnects the spinal cord, which is a process not seen in mammals. The findings could provide insights into potential therapies for spinal cord injuries in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced spinal cord injuries and are seeking innovative therapeutic options.
Not a fit: Patients with spinal cord injuries that are not amenable to regenerative therapies or those with conditions unrelated to spinal cord damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance spinal cord repair and recovery in patients with spinal cord injuries.
How similar studies have performed: Previous studies have shown that understanding regenerative mechanisms in model organisms like zebrafish can lead to breakthroughs in regenerative medicine, suggesting a promising avenue for this research.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Mokalled, Mayssa H. — Washington University
- Study coordinator: Mokalled, Mayssa H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.