How your genes affect risks and responses to cannabis
Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans
This project looks at how people's genes change their chances of addiction, psychosis, and thinking problems after using cannabis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11145912 on NIH RePORTER |
What this research studies
From your perspective, researchers will link DNA information with medical and drug-use histories to see who develops cannabis use disorder, psychosis, or cognitive problems after using cannabis. They will combine genetic data from large groups and use genome-wide analyses to find gene variants tied to these outcomes and to differences in responses to cannabinoid products and treatments. The team will also bring together clinical trial and cohort data to better understand genetic effects across different types of cannabis exposure and patient groups. Results are meant to point toward who might be at higher risk and which treatments might work better for certain genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates would be adults with current or past cannabis use—especially people with cannabis use disorder, cannabis-related psychosis, or cognitive complaints—who can provide consent, clinical information, and a DNA sample or allow use of existing data.
Not a fit: People who never use cannabis or who cannot or do not want to share genetic or clinical information are unlikely to see direct benefit from participating.
Why it matters
Potential benefit: If successful, this work could help identify people at higher risk from cannabis and guide more personalized prevention or treatment options.
How similar studies have performed: Previous genome-wide studies have found genetic links to cannabis use and related disorders, but the exact causal pathways and treatment-response effects are still unclear.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: D'souza, Deepak Cyril — Yale University
- Study coordinator: D'souza, Deepak Cyril
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.