How young children build number and space thinking in the brain

Early Spatial Cognition and the Neural Basis of Mathematics in Children

NIH-funded research Carnegie-Mellon University · NIH-11161308

Using non-invasive brain scans, researchers will look at how 4- to 8-year-old children's early number and space thinking links to their later school math skills.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionCarnegie-Mellon University NIH-funded
Lab location1 site (Pittsburgh, United States)
Project IDNIH-11161308 on NIH RePORTER

What this research studies

You or your child would join a multi-year project that follows kids from about 4 to 8 years old. Children will do simple number and space games while having functional MRI (fMRI) brain scans, with repeated visits over time to track development. The team will link early brain patterns to later classroom math performance, behavior, family learning activities, and will compare boys and girls. New statistical methods will be used to make the results more reliable and generalizable.

Who could benefit from this research

Good fit: Ideal participants are children aged about 4 to 8 years who can do simple game-like tasks and can safely have an fMRI scan (no metal implants and able to lie still).

Not a fit: Children who cannot tolerate MRI scanning, who have major neurological conditions that prevent safe participation, or who already have advanced math skills may not directly benefit from enrollment.

Why it matters

Potential benefit: If successful, this work could reveal early brain signs that predict later math difficulties so children can get targeted support sooner.

How similar studies have performed: Behavioral studies have linked early spatial-number skills to later math, but longitudinal fMRI evidence connecting early brain patterns to later school math is largely new.

Where this research is happening

Pittsburgh, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.