How Yersinia pestis uses yersiniabactin to survive in the body without iron
Iron independent role for yersiniabactin in Yersinia pestis
This study is looking at how the plague bacteria, Yersinia pestis, manages to survive in our bodies by using a special molecule called yersiniabactin to get important metals like iron and zinc, and it's aimed at finding new ways to help prevent or treat plague infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-11142487 on NIH RePORTER |
What this research studies
This research investigates how the bacterium Yersinia pestis, which causes the plague, survives in the human body despite the host's efforts to limit essential metals like iron and zinc. The study focuses on a molecule called yersiniabactin, which helps the bacteria acquire these metals, even in the absence of iron. By understanding these mechanisms, researchers aim to identify new therapeutic targets that could prevent or treat plague infections. The research employs various laboratory techniques, including mouse models, to explore the role of yersiniabactin in bacterial virulence and its interaction with host immune responses.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals at risk of plague exposure or those with compromised immune systems.
Not a fit: Patients who are not at risk for plague or do not have underlying health conditions that could be affected by this research may not receive any benefit.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or preventive measures against plague infections.
How similar studies have performed: Other research has shown success in targeting bacterial metal acquisition mechanisms, indicating that this approach has potential for meaningful advancements.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Lawrenz, Matthew B — University of Louisville
- Study coordinator: Lawrenz, Matthew B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.