How yeast pathogens adapt their stress response mechanisms over time
Evolution of Stress Response Gene Regulatory Network in a Commensal and Opportunistic Yeast Pathogen
This study looks at how certain yeast, which can cause infections, adapt to tough conditions and survive, especially when they don't have enough phosphate, to help us find better ways to treat yeast infections in patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10895593 on NIH RePORTER |
What this research studies
This research investigates the evolution of gene regulatory networks in yeast pathogens, specifically focusing on how these changes affect their ability to survive and cause disease in hosts. By studying the opportunistic yeast Candida glabrata, the researchers aim to understand the genetic and mechanistic bases of its stress responses, particularly in relation to phosphate starvation. The project will explore how these adaptations contribute to the yeast's virulence and resilience under various stress conditions. Patients may benefit from insights gained about yeast infections and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with recurrent yeast infections or those at risk for opportunistic infections.
Not a fit: Patients with non-yeast related infections or conditions unrelated to opportunistic fungal pathogens may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for yeast infections in patients.
How similar studies have performed: Other research has shown success in understanding gene regulatory networks in various organisms, suggesting that this approach could yield valuable insights, although the specific focus on Candida glabrata may be novel.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: He, Bin Z — University of Iowa
- Study coordinator: He, Bin Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.