How yeast adapt and evolve traits related to antibiotic resistance
Official title: Genetic interactions and the evolution of complex traits in yeast
Funded at Lehigh University · NIH-11060862 · Data updated 2026-11-12
This study looks at how yeast change and adapt when faced with challenges like antibiotics, helping us understand the genetic changes that lead to antibiotic resistance, which could ultimately help improve treatments for infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lehigh University NIH-funded |
| Lab location | 1 site (Bethlehem, United States) |
| Project start | May 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $367,976 |
| NIH project number | 5R35GM149540-03 |
| Project ID | NIH-11060862 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
✕Less likely to help
Patients with infections that are not caused by antibiotic-resistant organisms may not benefit from this research.
What this research studies
This research investigates how yeast evolve and adapt to environmental pressures, particularly focusing on antibiotic resistance. By using experimental evolution techniques, researchers will create and monitor many identical yeast populations over thousands of generations to observe how genetic changes lead to new traits. This approach allows for a detailed understanding of the genetic mechanisms behind adaptation, which could inform strategies to combat antibiotic resistance and improve treatment outcomes for various conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for overcoming antibiotic resistance and improving treatment options for patients with resistant infections.
How similar studies have gone: Other research has shown success in using experimental evolution to understand genetic adaptation, making this approach promising for addressing antibiotic resistance.
Where this research is happening
-
Lehigh University
Bethlehem, United States Active
Researchers
- Principal investigator: Lang, Gregory I — Lehigh University
- Study coordinator: Lang, Gregory I
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.