How wildfire pollution affects asthma through genetic factors
Transcriptional Responses to Wildfire Pollution in Airway Epithelial Cells Identify Genetic Risk Factors and Mechanisms of Asthma Exacerbations
['FUNDING_CAREER'] · NATIONAL JEWISH HEALTH · NIH-10994627
This study is looking at how breathing in smoke from wildfires affects asthma symptoms by testing airway cells in the lab, and it's aimed at helping people with asthma understand why some may struggle more with pollution than others.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NATIONAL JEWISH HEALTH (nih funded) |
| Locations | 1 site (DENVER, UNITED STATES) |
| Trial ID | NIH-10994627 on ClinicalTrials.gov |
What this research studies
This research investigates how exposure to wildfire pollution impacts asthma symptoms by examining airway epithelial cells. The team will expose these cells to wood smoke particles and analyze their genetic responses using advanced sequencing techniques. By identifying specific genetic variants linked to asthma exacerbations, the study aims to uncover the mechanisms that make some individuals more susceptible to worsening asthma due to air pollution. This work could lead to better understanding and management of asthma in polluted environments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with asthma who experience exacerbations during wildfire events.
Not a fit: Patients without asthma or those who do not experience exacerbations related to air pollution may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized strategies for preventing asthma exacerbations triggered by wildfire pollution.
How similar studies have performed: Previous research has shown that understanding genetic factors in response to environmental pollutants can lead to significant advancements in asthma management.
Where this research is happening
DENVER, UNITED STATES
- NATIONAL JEWISH HEALTH — DENVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUPTA, ARNAV — NATIONAL JEWISH HEALTH
- Study coordinator: GUPTA, ARNAV
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.