How where you live shapes midlife disability and thinking skills

Implications of residential location in midlife disability and cognitive functioning among the poor vs. rich: within the US and cross-country comparisons

NIH-funded research University of Michigan at Ann Arbor · NIH-11235917

This project looks at how neighborhood, county, and state environments across a person’s life relate to disability and thinking skills in midlife, and how those links differ for poorer versus richer adults in the U.S. and other countries.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Michigan at Ann Arbor NIH-funded
Lab location1 site (Ann Arbor, United States)
Project IDNIH-11235917 on NIH RePORTER

What this research studies

We compare adults with similar personal backgrounds who live in different neighborhoods to see whether area-level factors like social vulnerability, the built environment, local programs, and state policies are tied to midlife disability and cognitive function. The team uses life-history data to map residential histories over the life course and applies quasi-experimental methods to better separate neighborhood effects from individual traits. Analyses use measures at tract, county, and state levels and then compare U.S. findings to patterns in other high-income countries. Findings aim to point to neighborhood or policy targets that could reduce widening health disparities in working-age adults.

Who could benefit from this research

Good fit: Ideal candidates are adults in midlife or working age who can provide or allow access to their residential history and information about disability and cognitive function.

Not a fit: People seeking immediate clinical treatments or those without residential history data are unlikely to directly benefit from this observational research.

Why it matters

Potential benefit: If successful, this work could identify neighborhood changes or policy actions that help lower disability and slow cognitive decline in midlife, especially for disadvantaged groups.

How similar studies have performed: Prior studies have linked neighborhood context to health and cognition, but the combination of life-course residential histories and cross-country comparison in this project is relatively novel.

Where this research is happening

Ann Arbor, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.