NIH-funded research R01 grant

How where you live affects health and cognitive function in midlife

Official title: Implications of residential location in midlife disability and cognitive functioning among the poor vs. rich: within the US and cross-country comparisons

Funded at University of Michigan at Ann Arbor · NIH-10986122 · Data updated 2026-11-12

This study looks at how where you live affects the health and thinking abilities of adults in their middle years, especially comparing those from low-income and high-income backgrounds, to help understand why some people face more health challenges than others.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Michigan at Ann Arbor
NIH-funded
Lab location1 site (Ann Arbor, United States)
Project startDecember 15, 2022
Project endNovember 30, 2027
Funding year2025
Award (this year)$536,728
NIH project number5R01AG080491-03
Project IDNIH-10986122 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are midlife adults living in diverse socioeconomic environments across the United States.

Less likely to help

Patients who are not in the midlife age range or those living in homogeneous socioeconomic areas may not benefit from this research.

What this research studies

This research investigates how residential location impacts disability and cognitive functioning among adults in midlife, particularly comparing those from poorer and richer backgrounds. By analyzing various contextual factors such as social vulnerability and healthcare policies at different geographic levels, the study aims to identify which elements contribute to health disparities. The researchers will use a quasi-experimental approach to compare individuals with similar characteristics living in different environments, leveraging life-history data to understand long-term effects. This comprehensive analysis seeks to clarify the multi-level factors influencing health outcomes in the U.S.

Why it matters

Potential benefit: If successful, this research could lead to targeted interventions that improve health outcomes and reduce disparities for midlife adults based on their residential context.

How similar studies have gone: Previous research has shown that contextual factors significantly influence health outcomes, suggesting that this approach could yield valuable insights.

Where this research is happening

  • University of Michigan at Ann Arbor
    Ann Arbor, United States
    Active

Researchers

  • Principal investigator: Choi, Hwajung — University of Michigan at Ann Arbor
  • Study coordinator: Choi, Hwajung

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.