How well flu, COVID-19, and other respiratory vaccines prevent outpatient illness
RFA-IP-22-004, US Platform to Measure Effectiveness of Seasonal Influenza, COVID-19 and other Respiratory Virus Vaccines for the Prevention of Acute Illness in Ambulatory Settings
This project compares how well seasonal flu, COVID-19, and other respiratory vaccines keep people from getting sick enough to need outpatient care in community and household settings.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11141538 on NIH RePORTER |
What this research studies
This project follows people who visit outpatient clinics or live in households to track respiratory illnesses like influenza and COVID-19. Participating sites across the U.S. will use common protocols and standard procedures coordinated by Duke to collect information on symptoms, vaccination status, and lab test results. The network links clinic visit data, lab-confirmed infections, and vaccine records to measure how often vaccinated and unvaccinated people get symptomatic illness. Centralized data management and analysis will let researchers compare vaccine protection across seasons and different respiratory viruses.
Who could benefit from this research
Good fit: Ideal participants are people who seek outpatient care for cough, fever, or other respiratory symptoms and household members enrolled in community surveillance, including both vaccinated and unvaccinated individuals.
Not a fit: People who are hospitalized with severe disease, who do not seek outpatient care, or who live outside participating U.S. sites are unlikely to participate or gain direct benefit from this project.
Why it matters
Potential benefit: If successful, the project could help doctors and public health officials choose vaccines and strategies that better prevent outpatient respiratory illness and improve vaccination recommendations.
How similar studies have performed: Previous CDC and research-network efforts have successfully used outpatient and household surveillance to measure influenza and COVID-19 vaccine effectiveness, and this project builds on those established methods.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Walter, Emmanuel B — Duke University
- Study coordinator: Walter, Emmanuel B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.