How volatile anesthetics affect consciousness and metabolism
Volatile Anesthetics and Metabolism
['FUNDING_OTHER'] · SEATTLE CHILDREN'S HOSPITAL · NIH-11030292
This study is looking at how certain anesthetics make people temporarily unconscious and how our genes might affect how we respond to them, which could help make surgeries safer for everyone.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11030292 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which volatile anesthetics (VAs) induce a temporary loss of consciousness. By utilizing genetic models, the study examines how mitochondrial function influences sensitivity to VAs across different species, including humans. The research focuses on specific genetic alterations in mice to understand the role of astrocytes and other cell types in arousal and anesthetic-induced neurotoxicity. Patients may benefit from insights that could lead to safer anesthetic practices and improved outcomes during surgical procedures.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals undergoing surgical procedures requiring anesthesia.
Not a fit: Patients who are not undergoing surgery or do not require anesthesia may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer anesthetic techniques and better management of consciousness during surgery.
How similar studies have performed: Other research has shown promising results in understanding the effects of anesthetics on consciousness, but this approach is exploring novel mechanisms that have not been extensively tested.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORGAN, PHILIP G — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: MORGAN, PHILIP G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.